Schizophrenia: treatment

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Schizophrenia: treatment. Clozapine: this is the most effective, Olanzapine, Risperidone, Quetiapine, Paliperidone. Fully referenced neurology checklist.

Second generation antipsychotics

  • Clozapine: this is the most effective
  • Olanzapine
  • Risperidone
  • Quetiapine
  • Paliperidone
  • Ziprasidone
  • Molindone 

Third generation antipsychotics

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First generation antipsychotics: rarely used

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Non-drug treatments

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References

  1. Picchioni MM, Murray RM. Schizophrenia. BMJ 2007; 335:91-95. 
  2. Stępnicki P, Kondej M, Kaczor AA. Current concepts and treatments of schizophrenia. Molecules 2018; 23:2087.
  3. Faden J, Citrome L. Resistance is not futile: treatment-refractory schizophrenia - overview, evaluation and treatment. Expert Opin Pharmacother 2019; 20:11-24.
  4. Xu F, Xu S. Cognitive-behavioral therapy for negative symptoms of schizophrenia: A systematic review and meta-analysis. Medicine (Baltimore) 2024; 103:e39572.

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