Schizophrenia: pathology and risk factors
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Schizophrenia: pathology and risk factors. Dopaminergic, Glutamergic, Serotoninergic, GABAergic. Fully referenced neurology checklist.
Pathophysiological hypotheses
- Dopaminergic
- Glutamergic
- Serotoninergic
- GABAergic
- Others: histaminergic, muscarinergic, and adrenergic
Genetic risk factors: potential susceptibility genes
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Maternal risk factors
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Environmental risk factors
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References
- Picchioni MM, Murray RM. Schizophrenia. BMJ 2007; 335:91-95.
- Stępnicki P, Kondej M, Kaczor AA. Current concepts and treatments of schizophrenia. Molecules 2018; 23:2087.
- Martínez AL, Brea J, Rico S, de Los Frailes MT, Loza MI. Cognitive deficit in schizophrenia: from etiology to novel treatments. Int J Mol Sci 2021; 22:9905.
- Owen MJ, Sawa A, Mortensen PB. Schizophrenia. Lancet 2016; 388:86-97.
- Kiehl TR, Chow EW, Mikulis DJ, George SR, Bassett AS. Neuropathologic features in adults with 22q11.2 deletion syndrome. Cereb Cortex 2009; 19:153-164.
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