REM sleep behaviour disorder (RBD): management

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

REM sleep behaviour disorder (RBD): management. Clonazepam <2mg nocte. Fully referenced neurology checklist.

Main recommended drug treatments

  • Clonazepam <2mg nocte
  • Melatonin 3–12 mg taken 30 minutes before sleep

Drug treatments which may also worsen RBD

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Poorly evidenced drug treatments

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Environmental treatments

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Pressurised bed alarm

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References

  1. Aurora RN, Zak RS, Maganti RK, et al. Best practice guide for the treatment of REM sleep behaviour disorder (RBD). J Clin Sleep Med 2010; 15:85-95.
  2. Thomas A, Bonanni L, Onofrj M. Symptomatic REM sleep behaviour disorder. Neurol Sci 2007; 28:S21-S36.
  3. Wilson SJ, Nutt DJ, Argyropoulos SV, et al. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders. J Psychopharmacol 2010; 24:1577-1600.
  4. Iranzo A, Santamaria J, Tolosa E. Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions. Lancet Neurol 2016; 15:405-419. 
  5. Boeve BF. REM sleep behaviour disorder: updated review of the cite features, the RBD-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci 2010; 1184:15-54.
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