Rapidly progressive weakness: causes

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Rapidly progressive weakness: causes. Guillain Barre syndrome (GBS), Miller Fisher syndrome (MFS). Fully referenced neurology checklist.

Neuropathic causes

  • Guillain Barre syndrome (GBS)
  • Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
  • Miller Fisher syndrome (MFS)
  • Charcot Marie Tooth disease type 4J (CMT 4J)
  • Lead neuropathy

Myopathic causes

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Other neurological causes

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Infective causes

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Systemic causes

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References

  1. Bhidayasiri R, Waters MF, Giza CC. Neurological Differential Diagnosis. A Prioritized Approach. Blackwell Publishing Massachusetts 2005 pp272-273.
  2. Paganoni S, Quinn C, Salajegheh MK. Clinical Reasoning: A 20-year-old woman with rapidly progressive weakness. Neurology 2014; 82:e200-e204.
  3. Schreck KC, Schneider L, Geocadin RG. Clinical Reasoning: A 44-year-old woman with rapidly progressive weakness and ophthalmoplegia. Neurology 2015; 85:e22-e27. 
  4. Cottenie E, Menezes MP, Rossor AM, et al. Rapidly progressive asymmetrical weakness in Charcot–Marie–Tooth disease type 4J resembles chronic inflammatory demyelinating polyneuropathy. Neuromuscul Disord 2013; 23:399-403.

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