Neurological fatigue
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Neurological fatigue. Dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis, Impaired astroglial metabolism. Fully referenced neurology checklist.
Possible pathophysiological mechanisms
- Proinflammatory cytokines: TNF-alpha, interleukin 1β and interleukin 6
- Dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis
- Impaired astroglial metabolism
- Reduced noradrenaline and serotonin levels
Central causes
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Peripheral causes
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Factors that may worsen fatigue
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Differential diagnosis
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Non-drug treatments
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Drug treatments
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