Radiologically isolated syndrome (RIS): predictors of conversion to MS
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Radiologically isolated syndrome (RIS): predictors of conversion to MS. Younger age, Pregnancy. Fully referenced neurology checklist.
Clinical
- Younger age
- Pregnancy
- Abnormal visual evoked potentials (VEPs)
- Kapa free light chain index
Radiological
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Cerebrospinal fluid (CSF)
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Predictors of progression to primary progressive MS (PPMS)
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RIS conversion and progression rate to MS
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Acronyms
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References
- Granberg T, Martola J, Kristoffersen-Wiberg M, Aspelin P, Fredikson S. Radiologically isolated syndrome-incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review. Mult Scler 2013; 19:271-280.
- Siva A, Saip S, Altintas A, Jacob A, Kergan BM, Kantarci OH. Multiple sclerosis risk in radiologically uncovered asymptomatic possible inflammatory-demyelinating disease. Mult Scler 2009; 15:918-927.
- Lebrun C, LePage E, Kantarci O, et al. Impact of pregnancy on conversion to clinically isolated syndrome in a radiologically isolated syndrome cohort. Mult Scler 2012; 18:1297-1302.
- Levraut M, Gavoille A, Landes-Chateau C, et al. Kappa free light chain index predicts disease course in clinically and radiologically isolated syndromes. Neurol Neuroimmunol Neuroinflamm 2023; 10:e200156.
- Miller DH, Chard DT, Ciccarelli O. Clinically isolated syndromes. Lancet Neurol 2012; 11:157-169.
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