Progressive solitary sclerosis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Progressive solitary sclerosis. There is a single demyelinating corticospinal tract lesion. Fully referenced neurology checklist.
Defining features
- There is a single demyelinating corticospinal tract lesion
- It typically presents with progressive myelopathy
- There is progression of motor impairment for >1 year
- There are no other demyelinating lesions
- There is no history of relapses in other nervous system pathways
Clinical features
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Main differential diagnosis
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Magnetic resonance imaging (MRI)
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Cerebrospinal fluid (CSF) analysis
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Treatment
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References
- Keegan BM, Kaufmann TJ, Weinshenker BG, et al. Progressive solitary sclerosis: gradual motor impairment from a single CNS demyelinating lesion. Neurology 2016; 87:1713-1719.
- Schmalstieg WF, Keegan BM, Weinshenker BG. Solitary sclerosis: progressive myelopathy from solitary demyelinating lesion. Neurology 2012; 78:540-544.
- Rathnasabapathi D, Elsone L, Krishnan A, Young C, Larner A, Jacob A. Solitary sclerosis: Progressive neurological deficit from a spatially isolated demyelinating lesion: a further report. J Spinal Cord Med 2015; 38:551-555.
- Lattanzi S, Logullo F, Di Bella P, Silvestrini M, Provinciali L. Multiple sclerosis, solitary sclerosis or something else? Mult Scler 2014; 20:1819-1824.
