Peripheral nerve hyperexcitability (PNH): management
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Peripheral nerve hyperexcitability (PNH): management. Creatinine kinase (CK): this is raised in half of cases. Fully referenced neurology checklist.
Blood investigations
- Creatinine kinase (CK): this is raised in half of cases
- Anti-VGKC antibodies: these are present in 5-35% of cases
Electromyogram (EMG): features
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Paraneoplastic antibodies
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Treatment of neuromyotonia
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Immunosuppression
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Acronym
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References
- Hart IK, Maddison P, Newsome-Davis J, Vincent A, Mills KR. Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Brain 2002; 125:1887-1895.
- Rubio-Agusti I, Perez-Miralles F, Sevilla T, et al. Peripheral nerve hyperexcitability: a clinical and immunological study of 38 patients. Neurology 2011; 76:172-178.
- Maddison P. Neuromyotonia. Clin Neurophysiol 2006; 117:2118-2127.
- Skeie GO, Apostolski S, Evoli A, et al. Guidelines for the treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 2006; 13:691-699.
