Peripheral nerve hyperexcitability (PNH): causes

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Peripheral nerve hyperexcitability (PNH): causes. Thymoma, Thyroid cancer, Hodgkin lymphoma, Renal cell carcinoma. Fully referenced neurology checklist.

Paraneoplastic causes

  • Thymoma
  • Thyroid cancer
  • Hodgkin lymphoma
  • Renal cell carcinoma
  • Ovarian cancer

Immune causes

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Genetic causes

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Axonopathies

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Drug-induced and toxic causes

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Infectious causes

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Miscellaneous causes

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References

  1. Hart IK, Maddison P, Newsome-Davis J, Vincent A, Mills KR. Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Brain 2002; 125:1887-1895.
  2. Rubio-Agusti I, Perez-Miralles F, Sevilla T, et al. Peripheral nerve hyperexcitability: a clinical and immunological study of 38 patients. Neurology 2011; 76:172-178.
  3. Issa SS, Herskovitz S, Lipton RB. Acquired neuromyotonia as a paraneoplastic manifestation of ovarian cancer. Neurology 2011; 76:100-101.
  4. Wilson RH, Lehky T, Thomas RR, Quinn MG, Floeter MK, Grem JL. Acute oxaliplatin-induced peripheral nerve hyperexcitability. J Clin Oncol 2002; 20:1767-1774.
  5. Bolamperti L, Mula M, Varrasi C, et al. Generalized peripheral nerve hyperexcitability associated with lithium. J Neuropsychiatry Clin Neurosci 2009; 21:3.
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