Peripheral nerve hyperexcitability (PNH): clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Peripheral nerve hyperexcitability (PNH): clinical features. The average onset age is in the 5th decade. Fully referenced neurology checklist.

Onset features

  • The average onset age is in the 5th decade
  • The onset age may be as young as 9 years

Exercise-induced hyperexcitability symptoms

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Other muscle features

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Sensory features

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Central features

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Psychiatric features

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References

  1. Hart IK, Maddison P, Newsome-Davis J, Vincent A, Mills KR. Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Brain 2002; 125:1887-1895.
  2. Rubio-Agusti I, Perez-Miralles F, Sevilla T, et al. Peripheral nerve hyperexcitability: a clinical and immunological study of 38 patients. Neurology 2011; 76:172-178.
  3. Camelo CG, Silva AMS, Moreno CAM, et al. Facial myokymia in inherited peripheral nerve hyperexcitability syndrome. Pract Neurol 2020; 20:253-255. 

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