Periodic alternating nystagmus (PAN)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Periodic alternating nystagmus (PAN). This is nystagmus recurring in cycles. Fully referenced neurology checklist.

Clinical features

  • This is nystagmus recurring in cycles
  • There are transitional phases between the left and right beating phases
  • It may be congenital or acquired

Central causes

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Peripheral causes

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Treatment

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References

  1. Shallo-Hoffmann J, Riordan-Eva P. Recognizing periodic alternating nystagmus. Strabismus 2001; 9:203-215.  
  2. Colen CB, Ketko A, George E, Van Stavern GP. Periodic alternating nystagmus and periodic alternating skew deviation in spinocerebellar ataxia type 6. J Neuroophthalmol 2008; 28:287-288.
  3. Hashimoto T, Sasaki O, Yoshida K, Takei Y, Ikeda S. Periodic alternating nystagmus and rebound nystagmus in spinocerebellar ataxia type 6. Mov Disord 2003; 18:1201-1204. 
  4. Maramattom BV. Concurrent periodic alternating gaze deviation and periodic alternating nystagmus in brainstem glioma. Ann Indian Acad Neurol 2022; 25:274-275.
  5. Gorman WF, Brock S. Periodic alternating nystagmus in Friedreich's ataxia. Am J Ophthalmol 1950; 33:860-864.
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