Parkinson’s disease (PD): neurological risk factors
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Parkinson’s disease (PD): neurological risk factors. PD specific genes, Glucocerebrosidase (GBA) mutation. Fully referenced neurology checklist.
Genetic risk factors
- PD specific genes
- Glucocerebrosidase (GBA) mutation
- 22q11.2 chromosomal deletion
- Monogenic genes
- Family history of neurological disease
- Also see Neurochecklists: “PD genetics classification”
- Also see Neurochecklists topic :”PD genetic types”
Acquired risk factors
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Imaging risk factors
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Other neurological risk factors
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References
- Dekker MCJ, Bonifati V, van Duijn CM. Parkinson’s disease: piecing together a genetic jigsaw. Brain 2003; 126:1722-1733.
- Klein C, Westenberger A. Genetics of Parkinson's disease. Cold Spring Harb Perspect Med 2012; 2:a008888.
- Noyce AJ, R'Bibo L, Peress L, et al. PREDICT-PD: An online approach to prospectively identify risk indicators of Parkinson's disease. Mov Disord 2017; 32:219-226.
- Mok KY, Sheerin U, Simón-Sánchez J, et al. Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data. Lancet Neurol 2016; 15:585-596.
- Hubble JP, Cao T, Hassanein RES, Neuberger JS, Koller WC. Risk factors for Parkinson's disease. Neurology 1993; 43:1693-1697.
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