Paraneoplastic motor neurone disease (MND)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Paraneoplastic motor neurone disease (MND). The onset is subacute. Fully referenced neurology checklist.

Clinical features

  • The onset is subacute
  • It predominantly causes a lower motor neuron syndrome
  • It usually presents with asymmetric upper limb involvement
  • There may be associated upper motor neuron features
  • There may be associated sensory neuronopathy

Associated malignancies

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Paraneoplastic antibody tests

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Cerebrospinal fluid (CSF) analysis

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Other investigations

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Treatment

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References

  1. Mélé N, Berzero G, Maisonobe T, et al. Motor neuron disease of paraneoplastic origin: a rare but treatable condition. J Neurol 2018; 265:1590-1599.
  2. Diamanti L, Quaquarini E, Berzero G, et al. Lower motor neuron syndrome in a patient with HER2-positive metastatic breast cancer: a case report and review of the literature. Clin Neurol Neurosurg 2018; 172:141-142. 
  3. Sadot E, Carluer L, Corcia P, Delozier Y, Levy C, Viader F. Breast cancer and motor neuron disease: clinical study of seven cases. Amyotroph Lateral Scler 2007; 8:288-291.
  4. Forsyth PA, Dalmau J, Graus F, Cwik V, Rosenblum MK, Posner JB. Motor neuron syndromes in cancer patients. Ann Neurol 1997; 41:722-730.
  5. Diard-Detoeuf C, Dangoumau A, Limousin N, et al. Association of a paraneoplastic motor neuron disease with anti-Ri antibodies and a novel SOD1 I18del mutation. J Neurol Sci 2014; 337:212-214.
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