Mills variant motor neurone disease (MND):
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Mills variant motor neurone disease (MND). This is a hemiplegic variant of MND. Fully referenced neurology checklist.
Background
- This is a hemiplegic variant of MND
- It is possibly a variant of primary lateral sclerosis (PLS)
Clinical features
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Differential diagnosis
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Magnetic resonance imaging (MRI) brain
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Positron emission tomography (PET) scan
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References
- Wijesekera LC, Mathers S, Talman P, et al. Natural history and clinical features of the flail arm and flail leg ALS variants. Neurology 2009; 72:1087-1094.
- Rajabally YA, Hbahbih M, Abbott RJ. Hemiplegic ALS: Mills syndrome. Neurology 2005; 64:1984.
- Gastaut JL, Bartolomei F. Mills' syndrome: ascending (or descending) progressive hemiplegia: a hemiplegic form of primary lateral sclerosis? JNNP 1994; 57:1280-1281.
- Bäumer D, Butterworth R, Menke RA, Talbot K, Hofer M, Turner MR. Progressive hemiparesis (Mills syndrome) with aphasia in amyotrophic lateral sclerosis. Neurology 2014; 82:457-458.
- Jaiser SR, Mitra D, Williams TL, Baker MR. Mills' syndrome revisited. J Neurol 2019; 266:667-679.
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Related checklists
- C9orf72 variant motor neurone disease (MND): clinical features
- C9orf72 variant motor neurone disease (MND): investigations
- Flail arm syndrome (FAS) variant motor neurone disease (MND)
- Madras motor neuron disease (MMND)
- Motor neurone disease (MND): multisystem proteinopathy
- Paraneoplastic motor neurone disease (MND)
- Motor neurone disease (MND): FEWDON variant
- FUS variant motor neurone disease (MND)
- Motor neurone disease (MND): miscellaneous variants
