Opioid leukoencephalopathy
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Opioid leukoencephalopathy. Amnesia, Inattention, Disorientation, Seizures, Tremors, Dysautonomia, Rigidity, Fever. Fully referenced neurology checklist.
Acute toxic leukoencephalopathy (ATL): features
- Amnesia
- Inattention
- Disorientation
- Seizures
- Tremors
- Dysautonomia
- Rigidity
- Fever
- Hyperthermia
- Tachycardia
- Hypertension
- Rhabdomyolysis
- Coma
Delayed post-hypoxic leukoencephalopathy (DPHL): features
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Systemic features
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References
- Winstanley EL, Mahoney JJ 3rd, Castillo F, Comer SD. Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: a systematic review. Drug Alcohol Depend 2021; 226:108838.
- Knudsen GH, Kermanian N, Kock-Jensen CH, Antulov R. Opioid-induced leukoencephalopathies: a report of two cases. Case Rep Neurol 2022; 14:25-30.
