Non-Hodgkin’s lymphoma (NHL): neurological features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Non-Hodgkin’s lymphoma (NHL): neurological features. Age < 60 years, High-grade lymphoma. Fully referenced neurology checklist.
Risk factors for neurological involvement
- Age < 60 years
- High-grade lymphoma
- Raised serum lactate dehydrogenase (LDH)
- Hypoalbuminemia (< 35 g/L)
- Retroperitoneal lymph node involvement
- >1extranodal site involvement
Intracranial features
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Spinal features
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Peripheral nerve features
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Ophthalmic features
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References
- Giglio P, Gilbert MR. Neurologic complications of non-Hodgkin's lymphoma. Curr Hematol Malig Rep 2006; 1:214-219.
- Mead GM, Kennedy P, Smith JL, et al. Involvement of the central nervous system by non-Hodgkin's lymphoma in adults. A review of 36 cases. Q J Med 1986; 60:699-714.
- Zagami AS, Granot R. Non-Hodgkin's lymphoma involving the cauda equina and ocular cranial nerves: case reports and literature review. J Clin Neurosci 2003; 10:696-699.
- Wentzky P, Berndt S. Neuralgia of the trigeminal nerve as first symptom of a primary central nervous system lymphoma of non-Hodgkin's type. Fortschr Neurol Psychiatr 2003; 71:67-71.
- Gupta K, Radotra BD, Gupta V, Wanchu A. Concurrent presence of cryptococcal meningitis and primary central nervous system (CNS) non-Hodgkin's lymphoma in a non-HIV patient. Neuropathol Appl Neurobiol 2008; 34:241-244.
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