Neurolymphomatosis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Neurolymphomatosis. This is invasion of nerves by aggressive NHL. Fully referenced neurology checklist.
Pathology
- This is invasion of nerves by aggressive NHL
- It is usually caused by diffuse large cell B cell lymphoma (DLCBL)
- It may occur in the setting of Waldenstrom’s macroglobulinaemia
Classification
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Clinical features
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Differential diagnosis
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Investigations
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Treatment
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Prognosis
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References
- Baehring JM, Batchelor TT. Diagnosis and management of neurolymphomatosis. Cancer J 2012; 18:463-468.
- Lahoria R, Dyck PJ, Macon WR, et al. Neurolymphomatosis: a report of 2 cases representing opposite ends of the clinical spectrum. Muscle Nerve 2015; 52:449-454.
- Keddie S, Nagendran A, Cox T, et al. Peripheral nerve neurolymphomatosis: clinical features, treatment and outcomes. Muscle Nerve 2020 (Online ahead of print).
- Cox BC, Mauermann ML, Theel ES, Toledano M. Clinical Reasoning: Multifocal neuropathies in a patient with Waldenstrom macroglobulinemia and prior borreliosis. Neurology 2020; 95:44-48.
- Skolka MP, Suanprasert N, Martinez-Thompson JM, et al. Neurologic clinical, electrophysiologic, and pathologic characteristics of primary vs secondary neurolymphomatosis. Neurology 2024; 103:e209777.
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