Myoclonus: drug-induced

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Myoclonus: drug-induced. Nortriptyline, Selective serotonin reuptake inhibitors (SSRIs), Lithium, Venlafaxine. Fully referenced neurology checklist.

Antidepressants and antipsychotics

  • Nortriptyline
  • Selective serotonin reuptake inhibitors (SSRIs)
  • Lithium
  • Venlafaxine
  • Typical antipsychotics
  • Atypical antipsychotics e.g. Clozapine

Anti-epileptic drugs (AEDs)

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Antimicrobials

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Anti-Parkinsonian drugs

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Chemotherapy

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Anti-arrhythmics

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Other drugs

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References

  1. Kojovic M, Cordivari C, Bhatia K. Myoclonic disorders: a practical approach for diagnosis and treatment. Ther Adv Neurol Disord 2011; 4:47-62.
  2. Little JT, Jankovic J. Tardive myoclonus. Mov Disord 1987; 2:307-311.
  3. Jiménez-Jiménez FJ, Puertas I, de Toledo-Heras M. Drug-induced myoclonus: frequency, mechanisms and management. CNS Drugs 2004; 18:93-104. 
  4. Janssen S, Bloem BR, van de Warrenburg BP. The clinical heterogeneity of drug-induced myoclonus: an illustrated review. J Neurol 2017; 264:1559-1566. 
  5. Patterson JF. Myoclonus caused by a tricyclic antidepressant. South Med J 1990; 83:463-465.
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