Monomethyl fumarate
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Monomethyl fumarate. It is the active metabolite of dimethyl fumarate. Fully referenced neurology checklist.
Mode of action
- It is the active metabolite of dimethyl fumarate
- It reduces the level of circulating lymphocytes
- It also modifies monocyte activation
- It alters the transcription factor nuclear factor erythroid-derived 2-like 2 (NFE2L2 or NRF2)
Indications
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Dose
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Adverse effects
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Monitoring
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References
- Derfuss T, Mehling M, Papadopoulou A, Bar-Or A, Cohen JA, Kappos L. Advances in oral immunomodulating therapies in relapsing multiple sclerosis. Lancet Neurol 2020; 19:336-347.
- Berger AA, Sottosanti ER, Winnick A, et al. Monomethyl mumarate (MMF, Bafiertam) for the treatment of relapsing forms of multiple sclerosis (MS). Neurol Int 2021; 13:207-223.
