Langerhans cell histiocytosis (LCH): differential diagnosis

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Langerhans cell histiocytosis (LCH): differential diagnosis. Herpes simplex, Varicella, Seborrheic dermatitis. Fully referenced neurology checklist.

Cutaneous

  • Herpes simplex
  • Varicella
  • Seborrheic dermatitis
  • Xanthogranuloma
  • Scabies
  • Normolipemic granulomas
  • Histiocytomas
  • Haemophagocytic lymphohistiocytosis
  • Erythema toxicum
  • Mastocytosis
  • Infant leukaemia
  • Neuroblastoma
  • Scabies
  • Dermatopathic lesions

Orthopaedic

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Otorhinolaryngological

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Dental

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Hepatic

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Ophthalmic

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Pulmonary

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Gastrointestinal

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Synonym

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References

  1. Haupt R, Minkov M, Astigarraga I, et al. Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Pediatr Blood Cancer 2013; 60:175-184.
  2. Altay MA, Sindel A, Özalp Ö, et al. Langerhans cell histiocytosis: a diagnostic challenge in the oral cavity. Case Rep Pathol 2017; 2017:1691403.
  3. Donadieu J, Chalard F, Jeziorski E. Medical management of Langerhans cell histiocytosis from diagnosis to treatment. Expert Opin Pharmacother 2012; 13:1309-1322.
  4. Fu Z, Li H, Arslan ME, Ells PF, Lee H. Hepatic Langerhans cell histiocytosis: a review. World J Clin Oncol 2021; 12:335-341. 
  5. Cherian LM, Sasikumar D, Sathyan P, Varghese BE. Langerhans cell histiocytosis: a diagnostic enigma in the oral cavity. J Oral Maxillofac Pathol 2021; 25(Suppl 1):S27-S31. 
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