Inclusion body myositis (IBM): investigations
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Inclusion body myositis (IBM): investigations. This is normal or slightly raised. It is usually < 4 times normal. Fully referenced neurology checklist.
Creatinine kinase (CK)
- This is normal or slightly raised
- It is usually < 4 times normal
Electromyogram (EMG)
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Anti-cytosolic 5’-nucleotidase 1A (anti NT5c1A)
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Anti-cytosolic 5’-nucleotidase 1A (anti NT5c1A) antibodies: other causes
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Histopathological features
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Magnetic resonance imaging (MRI) muscle
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References
- Dabby R, Lange DJ, Trojaborg W, et al. Inclusion body myositis mimicking motor neuron disease. Arch Neurol 2001; 58:1253-1256.
- Tawara N, Yamashita S, Zhang X, et al. Pathomechanisms of anti-cytosolic 5'-nucleotidase 1A autoantibodies in sporadic inclusion body myositis. Ann Neurol 2017; 81:512-525.
- Herbert MK, Stammen-Vogelzangs J, Verbeek MM, et al. Disease specificity of autoantibodies to cytosolic 5′-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases. Ann Rheum Dis 2016; 75:696-701.
- Lilleker JB, Rietveld A, Pye SR, et al; all UKMYONET contributors. Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis. Ann Rheum Dis 2017; 76:862-868.
- Ikenaga C, Findlay AR, Goyal NA, et al. Clinical utility of anti-cytosolic 5'-nucleotidase 1A antibody in idiopathic inflammatory myopathies. Ann Clin Transl Neurol 2021; 8:571-578.
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