Immune mediated necrotising myopathy (IMNM): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Immune mediated necrotising myopathy (IMNM): clinical features. Anti SRP: this frequently involves the lungs. Fully referenced neurology checklist.
Antibody profile
- Anti SRP: this frequently involves the lungs
- Anti HMGCR: this is seen in statin exposed subjects
- Antibody negative (seronegative): this has a strong association with cancer
- Also see Neurochecklist: “IMNM: causes”
Clinical features
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Features of seronegative NAM
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Differential diagnosis
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Prognostic features
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Synonym
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References
- Kassardjian CD, Lennon VA, Alfugham NB, Mahler M, Milone M. Clinical features and treatment outcomes of necrotizing autoimmune myopathy. JAMA Neurol 2015; 72:996-1003.
- Meriggioli MN. The clinical spectrum of necrotizing autoimmune myopathy: a mixed bag with blurred lines. JAMA Neurol 2015; 72:977-979.
- Selva-O'Callaghan A, Pinal-Fernandez I, Trallero-Araguás E, Milisenda JC, Grau-Junyent JM, Mammen AL. Classification and management of adult inflammatory myopathies. Lancet Neurol 2018; 17:816-828.
- Soares IFZ, Comprido VF, Hsu BRRHS, Alves de Siqueira Carvalho A. Immune-mediated necrotising myopathy in asymptomatic patients with high creatine kinase. BMJ Case Rep 2020; 13:e235457.
- Lim J, Rietveld A, De Bleecker JL, et al. Seronegative patients form a distinctive subgroup of immune-mediated necrotizing myopathy. Neurol Neuroimmunol Neuroinflamm 2018; 6:e513.
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