Anti-SRP myopathy
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti-SRP myopathy. Anti SRP causes a form of immune mediated necrotizing myopathy (IMNM). Fully referenced neurology checklist.
Pathology
- Anti SRP causes a form of immune mediated necrotizing myopathy (IMNM)
- It is associated with HLA DRB1*08:03, B*5001, and DQA1*0104
- It has been associated with viral infections
Neurological features: limb weakness
Locked: subscribe to see this section.
Neurological features: others
Locked: subscribe to see this section.
Systemic features
Locked: subscribe to see this section.
Neurological investigations
Locked: subscribe to see this section.
Cardiac investigations
Locked: subscribe to see this section.
Treatment
Locked: subscribe to see this section.
Outcome
Locked: subscribe to see this section.
References
- Valiyil R, Casciola-Rosen L, Hong G, Mammen A, Christopher-Stine L. Rituximab therapy for myopathy associated with anti-signal recognition particle antibodies: a case series. Arthritis Care Res (Hoboken) 2010; 62:1328-1334.
- Hengstman GJ, ter Laak HJ, Vree Egberts WT, et al. Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis 2006; 65:1635-1638.
- Miller T, Al-Lozi MT, Lopate G, Pestronk A. Myopathy with antibodies to the signal recognition particle: clinical and pathological features. JNNP 2002; 73:420-428.
- Ma X, Bu BT. Anti-SRP immune-mediated necrotizing myopathy: a critical review of current concepts. Front Immunol 2022; 13:1019972.
- Iriki J, Yamamoto K, Senju H, et al. Influenza A (H3N2) infection followed by anti-signal recognition particle antibody-positive necrotizing myopathy: a case report. Int J Infect Dis 2021; 103:33-36.
- And 8 more. Subscribe to see the full list
