Immune mediated necrotising myopathy (IMNM): causes
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Immune mediated necrotising myopathy (IMNM): causes. Anti SRP: this is present in about a quarter of cases. Fully referenced neurology checklist.
Autoimmune
- Anti HMGCoA reductase: this is found in about a third of cases
- Anti SRP: this is present in about a quarter of cases
Statins
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Paraneoplastic
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Viral causes
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CHKB congenital muscular dystrophy
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Other causes
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Synonym
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Acronyms
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References
- Kassardjian CD, Lennon VA, Alfugham NB, Mahler M, Milone M. Clinical features and treatment outcomes of necrotizing autoimmune myopathy. JAMA Neurol 2015; 72:996-1003.
- Meriggioli MN. The clinical spectrum of necrotizing autoimmune myopathy: a mixed bag with blurred lines. JAMA Neurol 2015; 72:977-979.
- Babu S, Li Y. Statin induced necrotizing myopathy. J Neurol Sci 2015; 351:13-17.
- Mammen AL, Chung T, Christopher-Stine L, et al. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum 2011; 63:713-721.
- Babu S, Li Y. Statin induced necrotizing myopathy. J Neurol Sci 2015; 351:13-17.
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