HIV associated neurocognitive disorders (HAND): investigations

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

HIV associated neurocognitive disorders (HAND): investigations. This shows hyperintensities in the deep white matter and the basal ganglia.

Magnetic resonance imaging (MRI) brain

  • This shows hyperintensities in the deep white matter and the basal ganglia
  • The cortical U-fibers are spared unlike in PML

Positron emission tomography (PET) scan

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Other supporting imaging modalities

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Other investigations

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References

  1. Eggers C, Arendt G, Hahn K, et al; German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI). HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment. J Neurol 2017; 264:1715-1727. 
  2. Vera JH, Ridha B, Gilleece Y, Amlani A, Thorburn P, Dizdarevic S. PET brain imaging in HIV-associated neurocognitive disorders (HAND) in the era of combination antiretroviral therapy. Eur J Nucl Med Mol Imaging 2017; 44:895-902. 

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