Hereditary spastic paraplegia type 25 (SPG25)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Hereditary spastic paraplegia type 25 (SPG25). This is caused by mutations in chromosome 6q. Fully referenced neurology checklist.

Genetics

  • This is caused by mutations in chromosome 6q
  • The transmission is autosomal recessive
  • The onset is in adulthood

Clinical features

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Magnetic resonance imaging (MRI) spine: features

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References

  1. Zortea M, Vettori A, Trevisan CP, et al. Genetic mapping of a susceptibility locus for disc herniation and spastic paraplegia on 6q23.3-q24.1. J Med Genet 2002; 39:387-390.

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