Hereditary spastic paraplegia type 19 (SPG19)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Hereditary spastic paraplegia type 19 (SPG19). This is caused by mutations in chromosome 9q. Fully referenced neurology checklist.

Genetics

  • This is caused by mutations in chromosome 9q
  • The transmission is autosomal dominant
  • The onset is late
  • It causes a mild HSP phenotype

Clinical features

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Nerve conduction studies (NCS)

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References

  1. Valente EM, Brancati F, Caputo V, et al. Novel locus for autosomal dominant pure hereditary spastic paraplegia (SPG19) maps to chromosome 9q33-q34. Ann Neurol 2002; 51:681-685. 

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