Cerebral amyloid angiopathy (CAA): transient focal neurological episodes (TFNEs)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Cerebral amyloid angiopathy (CAA): transient focal neurological episodes (TFNEs). These are also called amyloid spells.

Description

  • These are also called amyloid spells
  • They are brief, multiple, and stereotyped attacks
  • They are responsive to antiepileptic drugs (AEDs)

Duration

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Migraine-like visual symptoms

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Other symptoms

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Implications

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References

  1. Charidimou A, Gang Q, Werring DJ. Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. JNNP 2012; 83:124-137.
  2. Banerjee G, Adams ME, Jaunmuktane Z, et al. Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura. Ann Neurol 2019; 85:284-290.
  3. Rannikmae K, Samarasekera N, Martinez-Gonzalez NA, Al-Shahi Salman R, Sudlow CLM. Genetics of cerebral amyloid angiopathy: systemic review and meta-analysis. JNNP 2013; 84:901-908.
  4. Sellimi A, Panteleienko L, Mallon D, et al. Inflammation in cerebral amyloid angiopathy-related transient focal neurological episodes. Ann Neurol 2025 (Online ahead of print).

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