Cerebral amyloid angiopathy (CAA): intracerebral haemorrhage (ICH)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Cerebral amyloid angiopathy (CAA): intracerebral haemorrhage (ICH). Peripheral, Cortical, Subcortical. Fully referenced neurology checklist.

Types

  • Peripheral
  • Cortical
  • Subcortical

Predictors

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Bleed characteristics

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Risk of secondary bleeding

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Risk factors for recurrent ICH

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References

  1. Charidimou A, Gang Q, Werring DJ. Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. JNNP 2012; 83:124-137.
  2. Chamarthy MR, Kumar Y, Meszaros MD, Shah A, Rosovsky MA. Isolated central sulcus hemorrhage: a rare presentation most frequently associated with cerebral amyloid angiopathy. Case Rep Radiol 2012; 2012:574849. 
  3. Arndt P, Pfister M, Perosa V, et al. Cerebrospinal fluid amyloid-β biomarkers predict future hemorrhage in patients with cerebral amyloid angiopathy. Ann Neurol 2026; 100:391-399.
  4. Pasi M, Boulouis G, Fotiadis P, et al. Distribution of lacunes in cerebral amyloid angiopathy and hypertensive small vessel disease. Neurology 2017; 88:2162-2168. 
  5. Samarasekera N, Smith C, Al-Shahi Salman R. The association between cerebral amyloid angiopathy and intracerebral haemorrhage: systematic review and meta-analysis. JNNP 2012; 83:275-281.
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