Calcifying pseudoneoplasms of the neuraxis (CAPNON)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Calcifying pseudoneoplasms of the neuraxis (CAPNON). These are slow-growing tumefactive lesions. Fully referenced neurology checklist.
Pathology
- These are slow-growing tumefactive lesions
- They can develop anywhere in the central nervous system
- They can be intra- or extra-axial
- They are non-infiltrative
- They cause mass effect
- They may be related to degenerative lesions of facet joint ligaments or synovial cysts
- There is a relationship with neurofilament light (NF-L) immunogenicity
Clinical features: cranial
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Clinical features: spinal
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Differential diagnosis: spinal
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Differential diagnosis: cranial
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Magnetic resonance imaging (MRI) features
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Computed tomography (CT) features
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Histopathology
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Treatment
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References
- Stienen MN, Abdulazim A, Gautschi OP, Schneiderhan TM, Hildebrandt G, Lücke S. Calcifying pseudoneoplasms of the neuraxis (CAPNON): clinical features and therapeutic options. Acta Neurochir (Wien) 2013; 155:9-17.
- Saha A, Arevalo-Perez J, Peck KK, Rosenblum M, Bilsky M, Lis E, Karimi S. Calcifying pseudoneoplasm of the spine: imaging and pathological features. Neuroradiol J 2018; 31:440-444.
- Yang K, Reddy K, Chebib I, Hammond R, Lu JQ. Calcifying pseudoneoplasm of the neuraxis: from pathogenesis to diagnostic and therapeutic considerations. World Neurosurg 2021; 148:165-176.
- Lyapichev K, Bregy A, Shah AH, Shah K, Desai MB, Petito C, Komotar RJ. Occipital calcified pseudoneoplasms of the neuraxis (CAPNON): understanding a rare pathology. BMJ Case Rep 2014; 2014:bcr2014206855.
- Fareez F, Yahya S, Fong C, et al. Spinal calcifying pseudoneoplasm of the neuraxis (CAPNON) associated with facet joint pathologies: CAPNON diagnostic and pathogenic insights. Hum Pathol 2024; 145:16-25.
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