Anti MGluR5 autoimmune encephalitis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti MGluR5 autoimmune encephalitis. This is caused by anti-metabotropic glutamate receptor 5 (MGluR5). Fully referenced neurology checklist.
Pathology
- This is caused by anti-metabotropic glutamate receptor 5 (MGluR5)
- It typically causes a cerebellitis
Causes
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Psychiatric features (Ophelia syndrome)
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Neurological features
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Cerebrospinal fluid (CSF) analysis
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Magnetic resonance imaging (MRI) brain
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Treatment
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References
- Lancaster E, Martinez-Hernandez E, Titulaer MJ, et al. Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome. Neurology 2011; 77:1698-1701.
- Spatola M, Sabater L, Planagumà J, et al. Encephalitis with mGluR5 antibodies: symptoms and antibody effects. Neurology 2018; 90:e1964-e1972.
- Mat A, Adler H, Merwick A, et al. Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF. Neurology 2013; 80:1349-1350.
- Chen S, Ren H, Lin F, et al. Anti-metabotropic glutamate receptor 5 encephalitis: five case reports and literature review. Brain Behav 2023; 13:e3003.
- Lancaster E. CNS syndromes associated with antibodies against metabotropic receptors. Curr Opin Neurol 2017; 30:354-360.
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