Anti GFAP autoimmune encephalitis: clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Anti GFAP autoimmune encephalitis: clinical features. Optic disc edema, Optic Papillitis: this may be bilateral. Fully referenced neurology checklist.

Ophthalmic features

  • Optic disc edema
  • Optic Papillitis: this may be bilateral
  • Optic neuritis: this may be isolated and relapsing
  • Visual loss

Movement disorders

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Other central neurological features

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Peripheral neurological features

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Differential diagnosis

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Prognosis

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Acronym

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References

  1. Fang B, McKeon A, Hinson SR, et al. Autoimmune glial fibrillary acidic protein astrocytopathy: a novel meningoencephalomyelitis. JAMA Neurol 2016; 73:1297-1307. 
  2. Flanagan EP, Hinson SR, Lennon VA, et al. Glial fibrillary acidic protein immunoglobulin G as biomarker of autoimmune astrocytopathy: analysis of 102 patients. Ann Neurol 2017; 81:298-309.
  3. Fang B, McKeon A, Hinson SR, Kryzer TJ, Pittock SJ, Aksamit AJ, Lennon VA. Autoimmune glial fibrillary acidic protein astrocytopathy: a novel meningoencephalomyelitis. JAMA Neurol 2016; 73:1297-1307.
  4. Zarkali A, Cousins O, Athauda D, Moses S, Moran N, Harikrishnan S. Glial fibrillary acidic protein antibody-positive meningoencephalomyelitis. Pract Neurol 2018; 18:315-319. 
  5. Chen JJ, Aksamit AJ, McKeon A, et al. Optic disc edema in glial fibrillary acidic protein autoantibody-positive meningoencephalitis. J Neuroophthalmol 2018; 38:276-281.
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