Zika virus infection (ZIKV): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Zika virus infection (ZIKV): clinical features. Microcephaly, White matter calcifications. Fully referenced neurology checklist.
Brain abnormalities
- Microcephaly
- White matter calcifications
- Dysgenesis of the corpus callosum and cerebellar vermis
- Ventriculomegaly
- Enlarged cisterna magna
- Cerebral atrophy
- Cerebellar hypoplasia
- Lissencephaly
- Hydrocephalus
Central neurological features
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Peripheral neurological features
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Ocular features
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Systemic features
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Differential diagnosis
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References
- Oliveira Melo AS, Malinger G, Ximenes R, Szejnfeld PO, Alves Sampaio S, Bispo de Filippis AM. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol 2016; 47:6-7.
- Melo AS, Aguiar RS, Amorim MM, et al. Congenital zika virus infection: beyond neonatal microcephaly. JAMA Neurol 2016; 73:1407-1416.
- van der Linden V, de Lima Petribu NC, Pessoa A, et al. Association of severe hydrocephalus with congenital zika syndrome. JAMA Neurol 2018; doi: 10.1001/jamaneurol.2018.3553 (Epub ahead of print).
- Jucá E, Pessoa A, Ribeiro E, et al. Hydrocephalus associated to congenital Zika syndrome: does shunting improve clinical features? Childs Nerv Syst 2018; 34:101-106.
- Carteaux G, Maquart M, Bedet A, et al. Zika virus associated meningoencephalitis. N Engl J Med 2016; 374:1595-1596.
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