Varicella zoster (VZV) vasculopathy: clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Varicella zoster (VZV) vasculopathy: clinical features. Immune compromise, HIV infection. Fully referenced neurology checklist.

Risk factors

  • Immune compromise
  • HIV infection
  • Systemic lupus erythematosus (SLE)
  • Rheumatoid arthritis
  • Steroid therapy
  • Natalizumab

Possible pathogenetic mechanisms

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Onset features

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Vascular features

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Non-vascular features

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References

  1. Gilden D, Cohrs RJ, Mahalingam R, Nagel MA. Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatment. Lancet Neurol 2009; 8:731-740.
  2. Nagel MA, Cohrs RJ, Mahalingam R, et al. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology 2008; 70:853-860.
  3. Bakradze E, Kirchoff KF, Antoniello D, et al. Varicella zoster virus vasculitis and adult cerebrovascular disease. Neurohospitalist 2019; doi.org/10.1177/1941874419845732 (Epub ahead of print).
  4. Nagel MA, Jones D, Wyborny A. Varicella zoster virus vasculopathy: the expanding clinical spectrum and pathogenesis. J Neuroimmunol 2017; 308:112-117.
  5. Williams L, Delaney F, Kenny G, et al. Varicella-zoster vasculopathy causing carotid artery dissection. Neurol Clin Pract 2021; 11:e373-e375.

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