Valproate: side effects
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Valproate: side effects. See Neurochecklist: “Foetal valproate spectrum disorder”. Fully referenced neurology checklist.
Foetal valproate spectrum disorder (FVSD)
- See Neurochecklist: “Foetal valproate spectrum disorder”
Hyperammonemia
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Movement disorders
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Other neurological side effects
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Systemic side effects
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Neurodevelopmental disorders with paternal valproate use
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References
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Lind J, Nordlund P. Intravenous use of valproic acid in status epilepticus is associated with high risk of hyperammonemia. Seizure 2019; 69:20-24.
- Panda S, Radhakrishnan K. Two cases of valproate-induced hyperammonemic encephalopathy without hepatic failure. J Assoc Physicians India 2004; 52:746-748.
- Chopra A, Kolla BP, Mansukhani MP, Netzel P, Frye MA. Valproate-induced hyperammonemic encephalopathy: an update on risk factors, clinical correlates and management. Gen Hosp Psychiatry 2012; 34:290-298.
- Wadzinski J, Franks R, Roane D, Bayard M. Valproate-associated hyperammonemic encephalopathy. J Am Board Fam Med 2007; 20:499-502.
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