Valproate: clinical use
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Valproate: clinical use. Valproate possibly enhances sodium channel inactivation. Fully referenced neurology checklist.
Mode of action
- Valproate possibly enhances sodium channel inactivation
Indications
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Dosing
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Drugs whose blood levels are increased by Valproate
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Drugs which increase Valproate blood levels
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Considerations for using Valproate in women of child-bearing potential
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Treatment of Valproate overdose
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References
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Macdonald RL, Kelly KM. Antiepileptic drug mechanisms of action. Epilepsia 1995; 36(Suppl 2):S2-S12.
- Johannessen SI, Landmark CJ. Antiepileptic drug interactions-principles and clinical implications. Curr Neuropharmacol 2010; 8:254-267.
- Wieck A, Jones S. Dangers of valproate in pregnancy. BMJ 2018; 361:k1609.
- Chopra A, Kolla BP, Mansukhani MP, Netzel P, Frye MA. Valproate-induced hyperammonemic encephalopathy: an update on risk factors, clinical correlates and management. Gen Hosp Psychiatry 2012; 34:290-298.
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