Type 1 interferonopathies
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Type 1 interferonopathies. These are autoimmune neuroinflammatory disorders. Fully referenced neurology checklist.
Pathology
- These are autoimmune neuroinflammatory disorders
- They result from overactivity of type I interferons
Common genetic mutations
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Clinical phenotypes
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Characteristic features
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Neuroradiological features
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Treatment
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Acronym
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References
- Günther C, Schmidt F, König N, Lee-Kirsch MA. Type I interferonopathies. Systemic inflammatory diseases triggered by type I interferons. Z Rheumatol 2016; 75:134-140.
- Lee-Kirsch MA, Wolf C, Kretschmer S, Roers A. Type I interferonopathies-an expanding disease spectrum of immunodysregulation. Semin Immunopathol 2015; 37:349-357.
- Volpi S, Picco P, Caorsi R, Candotti F, Gattorno M. Type I interferonopathies in pediatric rheumatology. Pediatr Rheumatol Online J 2016; 14:35.
- Papa R, Volpi S, Gattorno M. Monogenetic causes of chilblains, panniculitis and vasculopathy: the Type I interferonopathies. G Ital Dermatol Venereol 2020; 155:590-598.
- Benjamin P, Sudhakar S, D'Arco F, et al. Spectrum of neuroradiologic findings associated with monogenic interferonopathies. Am J Neuroradiol 2022; 43:2-10.
