Relapsing polychondritis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Relapsing polychondritis. This is an autoimmune recurrent inflammation of cartilage. Fully referenced neurology checklist.
Pathogenesis
- This is an autoimmune recurrent inflammation of cartilage
- It is possibly a medium and small vessel vasculitis
- There are antibodies to type II collagen
- It is associated with HLA-DR4 susceptibility
- Neurological involvement occurs in about 6% of cases
Central neurological features
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Peripheral neurological features
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Systemic features
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Associated autoimmune disorders
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Magnetic resonance imaging (MRI)
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Treatment
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References
- Wang ZJ, Pu CQ, Wang ZJ, et al. Meningoencephalitis or meningitis in relapsing polychondritis: four case reports and a literature review. J Clin Neurosci 2011; 18:1608-1615.
- Marie I, Levesque H, Cailleux N, Courtois H, Mihout B, Iasci L. Diplopia as the first manifestation of relapsing polychondritis. Ann Rheum Dis 1998; 57:634-635.
- Massry GG, Chung SM, Selhorst JB. Optic neuropathy, headache, and diplopia with MRI suggestive of cerebral arteritis in relapsing polychondritis. J Neuroophthalmol 1995; 15:171-175.
- Ragnaud JM, Tahbaz A, Morlat P, Sire S, Gin H, Aubertin J. Recurrent aseptic purulent meningitis in a patient with relapsing polychondritis. Clin Infect Dis 1996; 22:374-375.
- Zeuner M, Straub RH, Rauh G, Albert ED, Schölmerich J, Lang B. Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. J Rheumatol 1997; 24:96-101.
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