Thrombolysis: non-bleeding complications
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Thrombolysis: non-bleeding complications. This develops in about 27% of cases. Fully referenced neurology checklist.
Cerebral edema (CED)
- This develops in about 27% of cases
- It predicts poor outcome and mortality
Seizures
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New remote cerebral microbleeds
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Other complications
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Predictors of poor outcome
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References
- Thorén M, Azevedo E, Dawson J, et al. Predictors for cerebral edema in acute ischemic stroke treated with intravenous thrombolysis. Stroke 2017; 48:2464-2471.
- Xu Y, Hackett ML, Chalmers J, et al; ENCHANTED Study Group. Frequency, determinants, and effects of early seizures after thrombolysis for acute ischemic stroke: The ENCHANTED trial. Neurol Clin Pract 2017; 7:324-332.
- Braemswig TB, Villringer K, Turc G, et al. Predictors of new remote cerebral microbleeds after IV thrombolysis for ischemic stroke. Neurology 2019; 92:e630-e638.
- Miwa K, Koga M, Inoue M, et al. Cerebral microbleeds development after stroke thrombolysis: A secondary analysis of the THAWS randomized clinical trial. Int J Stroke 2021 (Online ahead of print).
- Miller DJ, Simpson JR, Silver B. Safety of thrombolysis in acute ischemic stroke: a review of complications, risk factors, and newer technologies. Neurohospitalist 2011; 1:138-147.
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