Suspected non-Alzheimer disease pathophysiology (SNAP)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Suspected non-Alzheimer disease pathophysiology (SNAP). This is an Alzheimer's disease (AD) like neurodegeneration. Fully referenced neurology checklist.
Definition
- This is an Alzheimer's disease (AD) like neurodegeneration
- It affects elderly adults without AD biomarkers
Clinical phenotypes
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Pathological features
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Imaging features
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References
- Jack CR Jr, Knopman DS, Chételat G, et al. Suspected non-Alzheimer disease pathophysiology-concept and controversy. Nat Rev Neurol 2016; 12:117-124.
- Yamada M. Suspected non-Alzheimer's disease pathophysiology (SNAP) and its pathological backgrounds in the diagnosis of preclinical and clinical Alzheimer's disease. Brain Nerve 2018; 70:59-71.
- Burnham SC, Bourgeat P, Doré V, et al; AIBL Research Group. Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study. Lancet Neurol 2016; 15:1044-1053.
- Caroli A, Prestia A, Galluzzi S, et al; Alzheimer's Disease Neuroimaging Initiative. Mild cognitive impairment with suspected nonamyloid pathology (SNAP): prediction of progression. Neurology 2015; 84:508-515.
