Susac syndrome: treatment

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Susac syndrome: treatment. Conservative management, Aspirin 75mg daily, Methylprednisolone IV 1g daily for 3-7 days. Fully referenced neurology checklist.

Treatment of mild cases

  • Conservative management
  • Aspirin 75mg daily
  • Methylprednisolone IV 1g daily for 3-7 days
  • Prednisolone PO 1mg/kg to maximum of 60mg daily for 4 weeks

Additional treatments of severe cases

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Maintenance treatments

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Treatments of retinal neovascularisation

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Other treatments

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Investigational treatments

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References

  1. Bose S, Papathanasiou A, Karkhanis S, et al. Susac syndrome: neurological update (clinical features, long-term observational follow-up and management of sixteen patients). J Neurol 2023 (Online ahead of print).
  2. Konitsioti AM, Grajewski R, Schlamann M, Schroeter M, Gereon RF, Warnke C. Successful natalizumab treatment of two female individuals with Susac syndrome. Eur J Neurol 2025; 32:e70103.

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