Status migrainosus

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Status migrainosus. These are prolonged migraine attacks. The attacks last >72 hours. They may be episodic. Fully referenced neurology checklist.

Clinical features

  • These are prolonged migraine attacks
  • The attacks last >72 hours
  • They may be episodic
  • They usually affect people with low frequency of migraine attacks
  • They recur in a third of cases

Triggers

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Pathology

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Secondary causes

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Drug treatments

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Non-drug treatments

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References

  1. Singh TD, Cutrer FM, Smith JH. Episodic status migrainosus: a novel migraine subtype. Cephalalgia 2018; 38:304-311.
  2. Beltramone M, Donnet A. Status migrainosus and migraine aura status in a French tertiary-care center: an 11-year retrospective analysis. Cephalalgia 2014; 34:633-637. 
  3. VanderPluym JH, Mangipudi K, Mbonde AA, et al. Incidence of status migrainosus in Olmsted County, Minnesota, United States: characterization and predictors of recurrence. Neurology 2023; 100:e255-e263.
  4. Gentile S, Rainero I, Daniele D, Binello E, Valfrè W, Pinessi L. Reversible MRI abnormalities in a patient with recurrent status migrainosus. Cephalalgia 2009; 29:687-690. 
  5. Nappi RE, Sances G, Brundu B, et al. Estradiol supplementation modulates neuroendocrine response to M-chlorophenylpiperazine in menstrual status migrainosus triggered by oral contraception-free interval. Hum Reprod 2005; 20:3423-3428.
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