Statin myopathy: clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Statin myopathy: clinical features. Myalgias with normal creatinine kinase (CK), Myopathy with normal CK. Fully referenced neurology checklist.
Presentations
- Myalgias with normal creatinine kinase (CK)
- Myopathy with normal CK
- Asymptomatic hyperCKaemia
- Myalgias with hyperCKaemia
- Statin necrotizing myopathy
- Weakness on pre-existing muscle diseases
- Acute quadriceps weakness
- Unmasking neuromuscular disorder
- Immune-mediated necrotising myopathy (IMNM)
Clinical features
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Necrotizing statin myopathy
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References
- Fernandez G, Spatz ES, Jablecki C, Phillips PS. Statin myopathy: a common dilemma not reflected in clinical trials. Cleve Clinic J Med 2011; 78:393-503.
- Grable-Esposito P, Katzberg HD, Greenberg SA, Srinivasan J, Katz J, Amato AA. Immune-mediated necrotizing myopathy associated with statins. Muscle Nerve 2010; 41:185-190.
- Bruckert E, Hayem G, Dejager S, et al. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study. Cardiovasc Drugs Ther 2005; 19:403-414.
- Sewright KA, Clarkson PM, Thompson PD. Statin myopathy: incidence, risk factors, pathophysiology. Curr Atheroscler Rep 2007; 9:389-396.
- Radcliffe KA, Campbell WW. Statin myopathy. Curr Neurol Neurosci Rep 2008; 8:66-72.
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