Small fiber neuropathy: treatment of neuropathic pain
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Small fiber neuropathy: treatment of neuropathic pain. Tricyclic antidepressants. Fully referenced neurology checklist.
First line treatments
- Tricyclic antidepressants
- Serotonin norepinephrine reuptake inhibitors (SNRIs)
- Calcium channel α-2-delta (CACNA2D) ligands
- 5% topical lidocaine patch
Second line treatments: opioids
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Third line treatments: antiepileptic drugs (AEDs)
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Third line treatments: others
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Fourth line treatments
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Investigational treatments
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Ineffective treatments
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References
- Dworkin RH, O'Connor AB, Backonja M, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007; 132:237-251.
- Moulin DE, Clark AJ, Gilron I, et al. Pharmacological management of chronic neuropathic pain-consensus statement and guidelines from the Canadian Pain Society. Pain Res Manage 2007; 12:13-21.
- Attal N, Cruccu G, Baron R, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol 2010; 17:1113-1123.
- Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol 2010; 9:807-819.
- Neuropathic pain: the pharmacological management of neuropathic pain in adults in non-specialist settings. NICE Clinical Guidance [CG96]. March 2010.
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