Small fiber neuropathy: investigations
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Small fiber neuropathy: investigations. von Frey hairs, Semmes-Weinstein monofilaments. Fully referenced neurology checklist.
Clinical
- von Frey hairs
- Semmes-Weinstein monofilaments
- Weighted needles and tuning forks
- Electronic vibrameter
- Thermal probes
- Assessment questionnaires: to discriminate pain mechanisms
Neurophysiological
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Evoked potentials
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Other tests
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References
- Lauria G, Hsieh ST, Johansson O, et al. European Federation of Neurological Societies/Peripheral Nerve Society guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur J Neurol 2010; 17:903-912.
- England JD, Gronseth GS, Franklin G, et al. Practice parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Neurology 2009; 72:177-184.
- Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol 2017; 16:934-944.
- Cruccu G, Sommer C, Anand P, et al. EFNS guidelines on neuropathic pain assessment: revised 2009. Eur J Neurol 2010; 17:1010-1018.
- Liguori R, Giannoccaro MP, Di Stasi V, et al. Microneurographic evaluation of sympathetic activity in small fiber neuropathy. Clin Neurophysiol 2011; 122:1854-1859.
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