Small fiber neuropathy: clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Small fiber neuropathy: clinical features. There is a trigger event in 80% of acute onset cases (AOSFN). Fully referenced neurology checklist.
Neuropathy pattern
- There is a trigger event in 80% of acute onset cases (AOSFN)
- It is typically non-length dependent
Neuropathic pain: features
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Sensory symptoms
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Autonomic symptoms
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Other symptoms
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Water immersion wrinkling test
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Progress and outcome
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References
- Devigili G, Tugnoli V, Penza P, et al. The diagnostic criteria for small fiber neuropathy: from symptoms to neuropathology. Brain 2008; 131:1912-1925.
- Tavee J, Zhou L. Small fiber neuropathy: a burning problem. Cleve Clin J Med 2009; 76:297-305.
- Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol 2017; 16:934-944.
- Gendre T, Lefaucheur J-P, Nordine T, et al. Characterizing acute-onset small fiber neuropathy. Neurol Neuroimmunol Neuroinflamm 2024; 11:e200195.
- Scadding J. Neuropathic pain. ACNR 2003; 3:8-14.
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