Small fiber neuropathy: causes
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Small fiber neuropathy: causes. Sodium channel gene mutations: Nav 1.7 channelopathy, Fabry disease, Tangier disease. Fully referenced neurology checklist.
Genetic
- Sodium channel gene mutations: Nav 1.7 channelopathy
- Fabry disease
- Tangier disease
- Familial amyloid polyneuropathy (FAP)
- COL6 gene mutation disorders
- Pompe disease
- Hereditary sensory and motor neuropathy (HSMN)
Immune and inflammatory
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Endocrine and metabolic
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Infections: major types
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Infections: other types
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Toxic: main ones
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Toxic: others
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Vaccinations
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Other causes
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Causes of loss of small fibers
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References
- Devigili G, Tugnoli V, Penza P, et al. The diagnostic criteria for small fiber neuropathy: from symptoms to neuropathology. Brain 2008; 131:1912-1925.
- Tavee J, Zhou L. Small fiber neuropathy: a burning problem. Cleve Clin J Med 2009; 76:297-305.
- Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol 2017; 16:934-944.
- Hoeijmakers JG, Han C, Merkies IS, et al. Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation. Brain 2012; 135:345-358.
- Han C, Hoeijmakers JG, Ahn HS, et al. Nav1.7-related small fiber neuropathy: impaired slow-inactivation and DRG neuron hyperexcitability. Neurology 2012; 78:1635-1643.
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