Sickle cell disease (SCD): systemic features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Sickle cell disease (SCD): systemic features. Anaemia. Fully referenced neurology checklist.

Haematological features

  • Anaemia

Infective features

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Cardiorespiratory features

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Gastrointestinal features

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Orthopaedic features

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Vascular features

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Vestibulochochlear features

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Sickle retinopathy

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Renal features

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Emerging potential autoimmune associations

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Socioeconomic impact

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References

  1. Childs JW. Sickle cell disease: the clinical manifestations. J Am Osteopath Assoc 1995; 95:593-598. 
  2. Serjeant GR. The clinical features of sickle cell disease. Baillieres Clin Haematol 1993; 6:93-115. 
  3. Powars DR, Chan LS, Hiti A, Ramicone E, Johnson C. Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients. Medicine (Baltimore) 2005; 84:363-376.
  4. Lionnet F, Hammoudi N, Stojanovic KS, et al. Hemoglobin sickle cell disease complications: a clinical study of 179 cases. Haematologica 2012; 97:1136-1141. 
  5. Dembélé AK, Toure BA, Sarro YS, et al. Prevalence and risk factors for sickle retinopathy in a sub-Saharan comprehensive Sickle Cell Center. Rev Med Interne 2017; pii: S0248-8663(17)30033-4 (Epub ahead of print).
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