Sickle cell disease (SCD): neurological features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Sickle cell disease (SCD): neurological features. Ischaemic: these account for 75% of strokes in SCD. Fully referenced neurology checklist.

Stroke: types

  • Ischaemic: these account for 75% of strokes in SCD
  • Intracerebral haemorrhage (ICH)
  • Subarachnoid haemorrhage (SAH)

Other haemorrhages

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Acute painful crisis

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Chronic pain

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Cerebral aneurysms

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Seizures: risk factors

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Other neurological features

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References

  1. DeBaun MR, Kirkham FJ. Central nervous system complications and management in sickle cell disease. Blood 2016; 127:829-838. 
  2. Noubiap JJ, Mengnjo MK, Nicastro N, Kamtchum-Tatuene J. Neurologic complications of sickle cell disease in Africa: a systematic review and meta-analysis. Neurology 2017; 89:1516-1524. 
  3. Noubiap JJ, Mengnjo MK, Nicastro N, Kamtchum-Tatuene J. Neurologic complications of sickle cell disease in Africa: a systematic review and meta-analysis. Neurology 2017; 89:1516-1524.  
  4. Kim S, Brathwaite R, Kim O. Evidence-Based Practice Standard Care for Acute Pain Management in adults with sickle cell disease in an urgent care center. Qual Manag Health Care 2017; 26:108-115. 
  5. Tanabe P, Hafner JW, Martinovich Z, Artz N. Adult emergency department patients with sickle cell pain crisis: results from a quality improvement learning collaborative model to improve analgesic management. Acad Emerg Med 2012; 19:430-438. 
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