Senile dementia of the neurofibrillary tangle type (SDNFT)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Senile dementia of the neurofibrillary tangle type (SDNFT). The mean onset age mean is 84 years. Fully referenced neurology checklist.
Epidemiological features
- The mean onset age mean is 84 years
- The mean age at death is 91 years
- The mean dementia duration is 7 years
Clinical features
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Pathological features
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SD-NFT v Alzheimer’s disease (AD) - AD has more severe of the following
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Diagnostic criteria
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Synonym
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References
- Tahara N, Tahara D, Akagi A, et al. Hippocampal sclerosis in senile dementia of the neurofibrillary tangle type. J Neurol Sci 2025; 471:123437.
- Matsubara T, Ishii K, Saito Y, et al. Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy. Acta Neuropathol Commun 2024; 12:98.
- Yamada M, Itoh Y, Sodeyama N, et al. Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Dement Geriatr Cogn Disord 2001; 12:117-126.
- Yamada M, Itoh Y, Suematsu N, Matsushita M. Dementia of the Alzheimer type and related dementias in the aged: DAT subgroups and senile dementia of the neurofibrillary tangle type. Neuropathology 1996.
- Jellinger KA, Attems J. Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease. Acta Neuropathol 2007; 113:107-117.
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